Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii.

نویسندگان

  • Marco Maria D'Andrea
  • Tommaso Giani
  • Silvia D'Arezzo
  • Alessandro Capone
  • Nicola Petrosillo
  • Paolo Visca
  • Francesco Luzzaro
  • Gian Maria Rossolini
چکیده

Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 53 8  شماره 

صفحات  -

تاریخ انتشار 2009